The RB596 antibody recognizes a linear epitope from the spike S protein from SARS-CoV-2

Authors

  • Lluc Farrera-Soler
  • Jean-Pierre Daguer
  • Sofia Barluenga
  • Nicolas Winssinger

DOI:

https://doi.org/10.24450/journals/abrep.2020.e232

Abstract

The recombinant antibody RB596 recognizes a linear epitope (residues 973-984, ISSVLNDILSRL) from the SARS-CoV-2 spike S protein.

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References

Farrera L, Daguer JP, Barluenga S, et al. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma. Preprint. medRxiv; 2020.2006. 2015.20131391. doi:10.1101/2020.06.15.20131391

Hammel P, Lau K, Pojer F, Hacker D, Marchetti A. The RB596 antibody recognizes the spike S protein from SARS-CoV-2 by ELISA. Antib. Rep. 2020a, 3:e218. doi:10.24450/journals/abrep.2020.e218

Hammel P, Marchetti A, Zenhausern F. AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by ELISA. Antib. Rep. 2020b, 3:e220. doi:10.24450/journals/abrep.2020.e220

Shah NB, Duncan TM. Bio-layer interferometry for measuring kinetics of protein-protein interactions and allosteric ligand effects. J Vis Exp. 2014; 84:e51383. PMID: 24638157

Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 2020; 181:281-292. PMID: 32155444

Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 2020; 367:1444-1448. PMID:32132184

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Published

2020-07-13 — Updated on 2023-03-03

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How to Cite

1.
Farrera-Soler L, Daguer J-P, Barluenga S, Winssinger N. The RB596 antibody recognizes a linear epitope from the spike S protein from SARS-CoV-2. Antib. Rep. [Internet]. 2023 Mar. 3 [cited 2023 Jun. 1];3(4):e232. Available from: https://oap.unige.ch/journals/abrep/article/view/232

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