AG424 and AG427 antibodies recognize the human TrkB protein by western blot

  • Audrey Roussel-Gervais
  • Stéphanie Sgroi
  • Vincent Jaquet

Abstract

The recombinant antibodies AG424 and AG427 detect the human TrkB protein in the human neural progenitor cell line ReNcell® VM and in human brain by western blot.

 

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References

Blaustein C. Use of TrkB antibodies for the treatment of respiratory disorders. USA; US20100297115, 2010.

Klein R, Conway D, Parada LF, Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 1990; 61:647-656. PMID: 2160854.

Lin CY, Chaparro RJF, Grishanin RN, Stratton JR, Zhai W. Agonist anti-TrkB monoclonal antibodies. USA; US20100196390, 2010.

Traub S, Stahl H, Rosenbrock H, et al. Pharmaceutical characterization of Tropomyosin Receptor Kinase B-agonistic antibodies on human induced pluripotent stem (hiPS) cell-derived neurons. J Pharmacol Exp Ther. 2017; 361:355-365. PMID: 28351853.

Published
04-09-2020
How to Cite
1.
Roussel-Gervais A, Sgroi S, Jaquet V. AG424 and AG427 antibodies recognize the human TrkB protein by western blot. Antib. Rep. [Internet]. 2020Sep.4 [cited 2020Nov.24];3(4):e240. Available from: https://oap.unige.ch/journals/abrep/article/view/240
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Article