Gut microbiota drive anti-viral immunity

Saskia Friederike Erttmann; Nelson Ong'ondo Gekara; Sun Nyunt Wai

doi:10.25250/thescbr.brk693

Authors

Saskia F. Erttmann Umeå University https://orcid.org/0000-0003-2398-8405
Nelson O. Gekara Stockholm University https://orcid.org/0000-0002-1269-8288
Sun Nyunt Wai Umeå University https://orcid.org/0000-0003-4793-4671

DOI:

https://doi.org/10.25250/thescbr.brk693

Keywords:

gut microbiota, bacterial membrane vesicles, systemic communication, anti-viral immunity, DNA sensor

Abstract

We investigated how the gut microbiota modulate anti-viral immunity in mouse models of infection. We showed that gut bacteria are vital for the presence of low level of type-I interferons, key mediators in anti-viral immunity. The gut bacteria deliver DNA in vesicles to host cells, priming anti-viral immunity.

Author Biographies

Saskia F. Erttmann, Umeå University

Assistant Professor of Cell and Molecular Biology

Nelson O. Gekara, Stockholm University

Professor of Molecular Immunology

Sun Nyunt Wai, Umeå University

Professor of Medical Microbial Pathogenesis

Original article reference

Erttmann, S. F., Swacha, P., Aung, K. M., Brindefalk, B., Jiang, H., Härtlova, A., Uhlin, B. E., Wai, S. N., & Gekara, N. O. (2022). The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis. Immunity, 55(5), 847-861.e10. https://doi.org/10.1016/j.immuni.2022.04.006