The RAINmakers: how receptors orchestrate specific cell functions

Authors

DOI:

https://doi.org/10.25250/thescbr.brk671

Keywords:

compartmentation, GPCR, cAMP, cell signaling, RAINs

Abstract

The exact interplay between receptors and their downstream signaling influences essentially all physiological functions. But how can a cell discriminate between hundreds of different receptors that share the same downstream signaling transducers? We find receptor-associated independent signaling nanodomains (RAINs) around single receptors which can specifically switch signaling cascades on or off.

Author Biographies

Charlotte Kayser, Max Delbrück Center for Molecular Medicine

Postdoctoral Research Fellow

Andreas Bock, Leipzig University

Professor

Original article reference

Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M. J., & Bock, A. (2022). Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell, 185(7), 1130-1142.e11. https://doi.org/10.1016/j.cell.2022.02.011

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Published

2023-02-02

Issue

Vol. 9 No. 1 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Charlotte Kayser, Andreas Bock

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.