The RAINmakers: how receptors orchestrate specific cell functions

Authors

DOI:

https://doi.org/10.25250/thescbr.brk671

Keywords:

compartmentation, GPCR, cAMP, cell signaling, RAINs

Abstract

The exact interplay between receptors and their downstream signaling influences essentially all physiological functions. But how can a cell discriminate between hundreds of different receptors that share the same downstream signaling transducers? We find receptor-associated independent signaling nanodomains (RAINs) around single receptors which can specifically switch signaling cascades on or off.

Author Biographies

  • Charlotte Kayser, Max Delbrück Center for Molecular Medicine

    Postdoctoral Research Fellow

  • Andreas Bock, Leipzig University

    Professor

Original article reference

Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M. J., & Bock, A. (2022). Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell, 185(7), 1130-1142.e11. https://doi.org/10.1016/j.cell.2022.02.011

Downloads

  • URL

Published

2023-02-02

Issue

Vol. 9 No. 1 (2023): TheScienceBreaker

Section

Health & Physiology

License

Copyright (c) 2023 Charlotte Kayser, Andreas Bock

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.