How do immune cells enter tissues to protect the body?

Authors

DOI:

https://doi.org/10.25250/thescbr.brk666

Keywords:

Immunology, Cell migration, Cell division, Fruit fly, Macrophage

Abstract

Immune cells can move within our body, even between firmly attached cells. How do they overcome these impediments? Studying fruit fly embryos, we have discovered that immune cells take advantage of dividing cells. Because intercellular attachments disassemble during division, it creates a weak spot in the dense tissue, through which immune cells can migrate.

Author Biographies

Maria Akhmanova, IST Austria

Postdoctoral Research Fellow

Daria Siekhaus, IST Austria

Visiting scientist

Original article reference

Akhmanova, M., Emtenani, S., Krueger, D., Gyoergy, A., Guarda, M., Vlasov, M., Vlasov, F., Akopian, A., Ratheesh, A., de Renzis, S., & Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration. Science, 376(6591), 394–396. https://doi.org/10.1126/science.abj0425

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Published

2023-01-06

Issue

Vol. 9 No. 1 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Maria Akhmanova, Daria Siekhaus

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.