An Antibody Cocktail Combats The Deadly Ebola Virus And Sudan Virus

Authors

DOI:

https://doi.org/10.25250/thescbr.brk701

Keywords:

antibody therapeutic, Bundibugyo virus, cryo-EM, Ebola virus, Sudan virus

Abstract

There are several deadly viruses in the ebola virus family, but current antibody treatments are effective against only one. Our work discovered two antibodies from human survivors, and their benefit when combined together in a cocktail, to provide broader protection at a lower dose. We reveal surprising findings of how they act to achieve protection.

Author Biographies

Xiaoying Yu, La Jolla Institute for Immunology

Postdoctoral Research Fellow

Erica Ollmann Saphire, La Jolla Institute for Immunology

Professor

Original article reference

Milligan, J. C., Davis, C. W., Yu, X., Ilinykh, P. A., Huang, K., Halfmann, P. J., Cross, R. W., Borisevich, V., Agans, K. N., Geisbert, J. B., Chennareddy, C., Goff, A. J., Piper, A. E., Hui, S., Shaffer, K. C. L., Buck, T., Heinrich, M. L., Branco, L. M., Crozier, I., … Saphire, E. O. (2022). Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell, 185(6), 995-1007.e18. https://doi.org/10.1016/j.cell.2022.02.023

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Published

2023-05-15

Issue

Vol. 9 No. 2 (2023): TheScienceBreaker

Section

Health & Physiology

License

Copyright (c) 2023 Xiaoying Yu, Erica Ollmann Saphire

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.