An Antibody Cocktail Combats The Deadly Ebola Virus And Sudan Virus
Keywords:antibody therapeutic, Bundibugyo virus, cryo-EM, Ebola virus, Sudan virus
There are several deadly viruses in the ebola virus family, but current antibody treatments are effective against only one. Our work discovered two antibodies from human survivors, and their benefit when combined together in a cocktail, to provide broader protection at a lower dose. We reveal surprising findings of how they act to achieve protection.
Original article reference
Milligan, J. C., Davis, C. W., Yu, X., Ilinykh, P. A., Huang, K., Halfmann, P. J., Cross, R. W., Borisevich, V., Agans, K. N., Geisbert, J. B., Chennareddy, C., Goff, A. J., Piper, A. E., Hui, S., Shaffer, K. C. L., Buck, T., Heinrich, M. L., Branco, L. M., Crozier, I., … Saphire, E. O. (2022). Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell, 185(6), 995-1007.e18. https://doi.org/10.1016/j.cell.2022.02.023
Copyright (c) 2023 Xiaoying Yu, Erica Ollmann Saphire
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