A blood cell atlas to guide us toward transplant success

Authors

  • Rafael D Melani Northwestern University
  • Josh Levitsky Northwestern University
  • Neil L Kelleher Northwestern University

DOI:

https://doi.org/10.25250/thescbr.brk685

Keywords:

proteoforms, blood cells, liver transplant, Proteomics

Abstract

Almost everything in our bodies is made from or by proteins. Just like reading a book opens a window to the world, studying these molecules helps us understand human physiology better. With this in mind, we created the first repository housing the exact composition of 57000 proteins in blood cells and managed to advance the prediction of whether liver transplant recipients may reject their graft

Author Biographies

Rafael D Melani, Northwestern University

Professor

Josh Levitsky, Northwestern University

Professor

Neil L Kelleher, Northwestern University

Professor

Original article reference

Melani, R. D., Gerbasi, V. R., Anderson, L. C., Sikora, J. W., Toby, T. K., Hutton, J. E., Butcher, D. S., Negrão, F., Seckler, H. S., Srzentić, K., Fornelli, L., Camarillo, J. M., LeDuc, R. D., Cesnik, A. J., Lundberg, E., Greer, J. B., Fellers, R. T., Robey, M. T., DeHart, C. J., … Kelleher, N. L. (2022). The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells. Science, 375(6579), 411–418. https://doi.org/10.1126/science.aaz5284

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Published

2023-03-08

Issue

Vol. 9 No. 1 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Rafael D Melani, Josh Levitsky, Neil L Kelleher

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.