Solving the puzzle behind COVID-19 induced smell loss

Authors

  • Marianna Zazhytska Columbia University in the City of New York https://orcid.org/0000-0002-6874-8272
  • Jonathan B. Overdevest Department of Otolaryngology, Head and Neck Surgery, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA https://orcid.org/0000-0002-1152-2512

DOI:

https://doi.org/10.25250/thescbr.brk640

Keywords:

COVID-19, anosmia, nuclear organization, olfactory receptors

Abstract

The SARS-CoV-2 virus rarely infects olfactory sensory neurons, yet causes widespread anosmia. Explaining this seeming paradox is that odor detection is impaired due to virus-mediated disruption of nuclear architecture that results in olfactory receptor and associated downregulation of signaling genes.

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Published

2022-07-18

Issue

Vol. 8 No. 3 (2022)

Section

Neurobiology

License

Some rights reserved 2022 Marianna Zazhytska, Jonathan B. Overdevest

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.