Two hits in one – the neurobiology of schizophrenia
DOI:
https://doi.org/10.25250/thescbr.brk669Keywords:
psychiatric genetics, schizophrenia, pathobiology, neurodevelopment, stem cell differentiationAbstract
Schizophrenia is widely thought to involve the disruption of both early and late phases of brain development – the so-called ‘two-hit’ hypothesis – but what is the biology behind these two hits? Studying genetic changes contributing to risk for the disorder, we uncovered surprising links between the biological pathways involved in early and late hits.
Original article reference
Sanders, B., D’Andrea, D., Collins, M. O., Rees, E., Steward, T. G. J., Zhu, Y., Chapman, G., Legge, S. E., Pardiñas, A. F., Harwood, A. J., Gray, W. P., O’Donovan, M. C., Owen, M. J., Errington, A. C., Blake, D. J., Whitcomb, D. J., Pocklington, A. J., & Shin, E. (2022). Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications, 13(1), 27. https://doi.org/10.1038/s41467-021-27601-0
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Some rights reserved 2023 Andrew Pocklington
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