Reversible Anticoagulants: Inspired by Nature, Designed for Safety

Authors

DOI:

https://doi.org/10.25250/thescbr.brk786

Keywords:

Supramolecular chemistry, Reversible Drug, Anti-coagulant

Abstract

Upon biting, blood sucking insects inject an anti-coagulant to enjoy their meal. These anti-coagulants have inspired approved drug. Combining this concept with supramolecular chemistry, we developed a novel bi-functional drug. It shows strong in vivo effects and can be reversed with an 'antidote,' a sought-after trait in anti-coagulant treatments. This property extends to other therapies like immunotherapies, broadening its potential impact on diverse medical applications.

Author Biographies

  • Milly, University of Geneva

    PhD student

  • Nicolas Winssinger, University of Geneva

    Professor

Original article reference

Dockerill, M., Ford, D. J., Angerani, S., Alwis, I., Dowman, L. J., Ripoll-Rozada, J., Smythe, R. E., Liu, J. S. T., Pereira, P. J. B., Jackson, S. P., Payne, R. J., & Winssinger, N. (2024). Development of supramolecular anticoagulants with on-demand reversibility. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02209-z

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Published

2024-06-12

Issue

Vol. 10 No. 2 (2024): TheScienceBreaker

Section

Maths, Physics & Chemistry

License

Copyright (c) 2024 Milly, Nicolas Winssinger

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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.