Reversible Anticoagulants: Inspired by Nature, Designed for Safety

Authors

DOI:

https://doi.org/10.25250/thescbr.brk786

Keywords:

Supramolecular chemistry, Reversible Drug, Anti-coagulant

Abstract

Upon biting, blood sucking insects inject an anti-coagulant to enjoy their meal. These anti-coagulants have inspired approved drug. Combining this concept with supramolecular chemistry, we developed a novel bi-functional drug. It shows strong in vivo effects and can be reversed with an 'antidote,' a sought-after trait in anti-coagulant treatments. This property extends to other therapies like immunotherapies, broadening its potential impact on diverse medical applications.

Author Biographies

Milly, University of Geneva

PhD student

Nicolas Winssinger, University of Geneva

Professor

Original article reference

Dockerill, M., Ford, D. J., Angerani, S., Alwis, I., Dowman, L. J., Ripoll-Rozada, J., Smythe, R. E., Liu, J. S. T., Pereira, P. J. B., Jackson, S. P., Payne, R. J., & Winssinger, N. (2024). Development of supramolecular anticoagulants with on-demand reversibility. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02209-z

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Published

2024-06-12

Issue

Vol. 10 No. 2 (2024): TheScienceBreaker

Section

Maths, Physics & Chemistry

License

Some rights reserved 2024 Milly, Nicolas Winssinger

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.