Tobacco smoking and other exposures shut off cancer-fighting genes
DOI:
https://doi.org/10.25250/thescbr.brk792Keywords:
cancer, mutations, genomicsAbstract
DNA mutations causing cancer occur in cells through aging, environmental exposures, and cellular factors. By analysing thousands of cancer genomes, we found that tobacco smoking, APOBEC enzymes, and oxidative stress often introduce harmful “stop-gain” mutations that disable genes. This study highlights how some lifestyle choices and cellular processes can modify genes that protect us from cancer.
Original article reference
Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes. Nina Adler, Alexander T. Bahcheli, Kevin C. L. Cheng, Khalid N. Al-Zahrani, Mykhaylo Slobodyanyuk, Diogo Pellegrina, Daniel Schramek, Jüri Reimand. Science Advances, 3 Nov 2023, Vol 9, Issue 44, DOI: 10.1126/sciadv.adh3083.
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Some rights reserved 2024 Jüri Reimand, Nina Adler
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