A hidden clock that times cytoplasmic divisions
DOI:
https://doi.org/10.25250/thescbr.brk790Keywords:
Cytoplasmic division, autonomous clocks, mitosis, Drosophila, epithelial homeostasisAbstract
Our recent study reveals that in fruit fly embryos, the cell's cytoplasm can divide on its own, without waiting for the nucleus or relying on the usual cell division signals. This discovery challenges what we thought we knew about how cells divide and opens up new questions about how these processes are controlled.
Original article reference
Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG. Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes. Cell. 2023 Oct 12;186(21):4694-4709.e16. doi: 10.1016/j.cell.2023.09.010. PMID: 37832525; PMCID: PMC10659773.
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