Keeping the balance: How epigenetics monitors cancer genes
DOI:
https://doi.org/10.25250/thescbr.brk784Keywords:
Epigenetics, Histones, DNA, Cancer biology, DNA replicationAbstract
Epigenetic regulation consists in chemical modifications on the proteins that organize DNA. Here, we show how it increases gene copies and rearranges the MLL gene, which associates with infant, adult, and therapy-associated leukemia.
These findings show how chemotherapy-induced MLL changes occur and provide a therapeutic way to prevent them.
Original article reference
Gray, Z. H., Chakraborty, D., Duttweiler, R. R., Alekbaeva, G. D., Murphy, S. E., Chetal, K., Ji, F., Ferman, B. I., Honer, M. A., Wang, Z., Myers, C., Sun, R., Kaniskan, H. Ü., Toma, M. M., Bondarenko, E. A., Santoro, J. N., Miranda, C., Dillingham, M. E., Tang, R., … Whetstine, J. R. (2023). Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell, 186(21), 4528-4545.e18. https://doi.org/10.1016/j.cell.2023.09.009
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Some rights reserved 2024 Zach Gray, Madison Honer, Johnathan Whetstine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
