Natural products might just be our best weapon against antibiotic resistance

Olivier Kirchhoffer; Jahn Nitschke; Jean-Luc Wolfender

doi:10.25250/thescbr.brk781

Authors

Olivier Kirchhoffer University of Geneva https://orcid.org/0000-0001-7567-1050
Jahn Nitschke University of Geneva https://orcid.org/0000-0003-3838-0945
Jean-Luc Wolfender University of Geneva https://orcid.org/0000-0002-0125-952X

DOI:

https://doi.org/10.25250/thescbr.brk781

Keywords:

Anti-mycobacterial, Large colletion of plants, Natural products, Structural similarity search

Abstract

Nature has always been an interesting source of chemical diversity for the search of molecules of therapeutic interest. Here we showed how large plant extract libraries can be transformed into a chemical library. This library could then be efficiently used to isolate molecules of unreported bioactivity to advance our knowledge on disease treatments.

Author Biographies

Olivier Kirchhoffer, University of Geneva

PhD student

Jahn Nitschke, University of Geneva

PhD student

Jean-Luc Wolfender, University of Geneva

Professor

Original article reference

Kirchhoffer OA, Nitschke J, Allard PM, Marcourt L, David B, Grondin A, et al. Targeted isolation of natural analogs of anti-mycobacterial hit compounds based on the metabolite profiling of a large collection of plant extracts. Frontiers in Natural Products. 2023;2. https://doi.org/10.3389/fntpr.2023.1279761