A softer touch to understand how cells function in different environments

Authors

DOI:

https://doi.org/10.25250/thescbr.brk805

Keywords:

Tissue mechanics, Cell biology, Cancer biology

Abstract

Challenging the belief that cells favor rigid environments, we find that certain protein combinations make soft surfaces as appealing as hard. Since the tissues inside our body are much softer than the glass or plastic used in research, it is important to better model the cells’ natural environment outside of the body for a higher fidelity view of how they function and how diseases develop.

 

 

Author Biographies

James Conway, Turku Bioscience Centre

Postdoctoral Research Fellow

Hellyeh Hamidi, Turku Bioscience Centre

Postdoctoral Researcher

Johanna Ivaska, Turku Bioscience Centre

Professor

Original article reference

Conway JRW, Isomursu A, Follain G, Härmä V, Jou-Ollé E, Rantala JK and Ivaska J (2023) Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling. PNAS 120(43): e2304288120.

https://pubmed.ncbi.nlm.nih.gov/37844244/

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Published

2026-07-14

Issue

Section

Health & Physiology