When two kinases go for a dance
DOI:
https://doi.org/10.25250/thescbr.brk788Keywords:
chemistry, Molecular Movies, kinases, Molecular Dynamics, P38aAbstract
Phosphorylation is a fundamental mechanism in eukaryotic cells that allows signals to propagate. Kinases orchestrate this process by phosphorylating proteins to modulate their activity. Our work reveals the architecture of the complex between two key players of the mitogen-activated protein kinase signaling pathway, p38α and MKK6, while also giving an idea of what happens when the two come together.
Original article reference
Juyoux, P., Galdadas, I., Gobbo, D., von Velsen, J., Pelosse, M., Tully, M., Vadas, O., Gervasio, F. L., Pellegrini, E., & Bowler, M. W. (2023). Architecture of the MKK6-p38a complex defines the basis of MAPK specificity and activation. Science, 381(6663), 1217–1225. https://doi.org/10.1126/science.add7859
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Some rights reserved 2024 Ioannis Galdadas, Francesco Luigi Gervasio, Pauline Juyoux
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.