HIV pushes the nuclear envelope to start an infection

Authors

DOI:

https://doi.org/10.25250/thescbr.brk765

Keywords:

virus, HIV, nuclear membrane, AIDS, nuclear transport

Abstract

Retroviruses like HIV-1 enter the nucleus of immune cells to infect people, but it has been unclear how a relatively large virus can pass through the nuclear envelope or its small nuclear pores. We found a previously unknown pathway of entry, in which a virus-containing package causes invaginations to form in the nuclear envelope. Our work reveals new drug targets for limiting viral infections.

Author Biographies

Cheryl Vanier, Touro University Nevada College of Medicine

Adjunct Faculty

Aurelio Lorico, Touro University Nevada College of Medicine

Professor

Original article reference

Santos, M.F., Rappa, G., Karbanová, J., Diana, P., Cirrincione, G., Carbone, D., Manna, D., Aalam, F., Wang, D., Vanier, C., Corbeil, D., Lorico, A. HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells. Nat Commun 14, 4588 (2023).

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Published

2023-11-14

Issue

Vol. 9 No. 4 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Cheryl Vanier, Aurelio Lorico

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.