Mutations in the germline: How the mother repairs the father’s damaged genome

Authors

DOI:

https://doi.org/10.25250/thescbr.brk762

Keywords:

inheritance, DNA repair, genome stability, mutations, genome

Abstract

Germline mutations can have a severe impact on genetic diseases, genome evolution and the fate of a species. The vast majority of inheritable mutations are passed on by the paternal genome. We discovered how paternal DNA damage is repaired by maternal repair leading to the inheritance of structural variants.

Author Biographies

  • Björn Schumacher, University of Cologne

    Principal Investigator

  • Siyao Wang

    Principal Investigator

  • David Meyer

    PhD studen

Original article reference

Wang, S., Meyer, D. H. & Schumacher, B. Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature 613, 365–374 (2023).

DNA

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Published

2023-10-27

Issue

Vol. 9 No. 4 (2023): TheScienceBreaker

Section

Health & Physiology

License

Copyright (c) 2023 Björn Schumacher, Siyao Wang, David Meyer

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.