Mutations in the germline: How the mother repairs the father’s damaged genome
DOI:
https://doi.org/10.25250/thescbr.brk762Keywords:
inheritance, DNA repair, genome stability, mutations, genomeAbstract
Germline mutations can have a severe impact on genetic diseases, genome evolution and the fate of a species. The vast majority of inheritable mutations are passed on by the paternal genome. We discovered how paternal DNA damage is repaired by maternal repair leading to the inheritance of structural variants.
Original article reference
Wang, S., Meyer, D. H. & Schumacher, B. Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature 613, 365–374 (2023).
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Some rights reserved 2023 Björn Schumacher, Siyao Wang, David Meyer
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.