Writing cell memory: how Histones play a role in Epigenetic Memory

Authors

DOI:

https://doi.org/10.25250/thescbr.brk751

Keywords:

Chromatin, Epigenetics, Histones, DNA replication

Abstract

Our cells remember their cell type-specific functions during their lifetime using modifications on histones, the proteins packaging DNA. Such epigenetic memory is challenged during DNA replication when histones are evicted from DNA. We reveal new evidence that cells recycle histones H2A-H2B to replicated DNA with their modifications, hereby providing epigenetic memory across cell division.

Author Biographies

Valentin Flury, University of Copenhagen

Postdoctoral Research Fellow

Anja Groth, University of Copenhagen

Professor

Original article reference

Flury, V., Reverón-Gómez, N., Alcaraz, N., Stewart-Morgan, K. R., Wenger, A., Klose, R. J., & Groth, A. (2023). Recycling of modified H2A-H2B provides short-term memory of chromatin states. Cell, 186(5), 1050-1065.e19. https://doi.org/10.1016/j.cell.2023.01.007

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Published

2023-10-03

Issue

Vol. 9 No. 4 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Valentin Flury, Anja Groth

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.