How HIV-infected cells use immune checkpoints to evade the human immune system

Authors

  • Marie Armani-Tourret Ragon Institute of MGH, MIT and Harvard
  • Mathias Lichterfeld Ragon Institute of MGH, MIT and Harvard https://orcid.org/0000-0001-9865-8350

DOI:

https://doi.org/10.25250/thescbr.brk748

Keywords:

HIV, immune response, sequencing, camouflage

Abstract

The human immune system is very effective in eliminating pathogens that attack us in everyday life. However, in the case of HIV infection, it fails to clear all infected cells, resulting in a disease that remains incurable to date. Our study reveals that HIV-infected cells express higher levels of immune checkpoint markers and 'do not kill me' signals, helping them evade immune detection.

Author Biographies

Marie Armani-Tourret, Ragon Institute of MGH, MIT and Harvard

Postdoctoral Research Fellow

Mathias Lichterfeld, Ragon Institute of MGH, MIT and Harvard

Professor 

 

Original article reference

Sun, W., Gao, C., Hartana, C.A. et al. Phenotypic signatures of immune selection in HIV-1 reservoir cells. Nature 614, 309–317 (2023). https://doi.org/10.1038/s41586-022-05538-8

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Published

2023-09-27

Issue

Vol. 9 No. 3 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 Marie Armani-Tourret, Mathias Lichterfeld

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.