Age-induced unsealing of the "Pandora's box": resurrection of endogenous retroviruses

xiaoqian liu; Jie Ren; Guang-Hui Liu

doi:10.25250/thescbr.brk745

Authors

xiaoqian liu Institute of Zoology , Institute of Zoology https://orcid.org/0000-0003-1022-9215
Jie Ren https://orcid.org/0000-0002-6450-3163
Guang-Hui Liu

DOI:

https://doi.org/10.25250/thescbr.brk745

Keywords:

Endogenous retroviruses, Aging, Epigenetics, Intervention

Abstract

Aging is like a box full of secrets. Inside this "Pandora's box" lies a ticking time bomb of viruses, obsolete from millions of years ago, called endogenous retroviruses (ERVs). Using different aging models and technologies, researchers have proven that the reactivation of ERVs acts as both a biomarker and driver of aging, which provides potential interventions to “control the plague” of aging.

Author Biographies

xiaoqian liu, Institute of Zoology, Institute of Zoology

Assistant Research Fellow
Jie Ren

Principal Investigator
Guang-Hui Liu

Professor

Original article reference

Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., Jiang, X., Wang, C., Wang, Q., Ji, Z., Li, L., Esteban, C. R., Yan, K., Li, W., Cai, Y., … Liu, G. H. (2023). Resurrection of endogenous retroviruses during aging reinforces senescence. Cell, 186(2). https://doi.org/10.1016/j.cell.2022.12.017