Age-induced unsealing of the "Pandora's box": resurrection of endogenous retroviruses

Authors

DOI:

https://doi.org/10.25250/thescbr.brk745

Keywords:

Endogenous retroviruses, Aging, Epigenetics, Intervention

Abstract

Aging is like a box full of secrets. Inside this "Pandora's box" lies a ticking time bomb of viruses, obsolete from millions of years ago, called endogenous retroviruses (ERVs). Using different aging models and technologies, researchers have proven that the reactivation of ERVs acts as both a biomarker and driver of aging, which provides potential interventions to “control the plague” of aging.

Author Biographies

xiaoqian liu, Institute of Zoology

Assistant Research Fellow

Jie Ren

Principal Investigator

Guang-Hui Liu

Professor

Original article reference

Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., Jiang, X., Wang, C., Wang, Q., Ji, Z., Li, L., Esteban, C. R., Yan, K., Li, W., Cai, Y., … Liu, G. H. (2023). Resurrection of endogenous retroviruses during aging reinforces senescence. Cell, 186(2). https://doi.org/10.1016/j.cell.2022.12.017

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Published

2023-09-19

Issue

Vol. 9 No. 3 (2023): TheScienceBreaker

Section

Health & Physiology

License

Some rights reserved 2023 xiaoqian liu, Jie Ren, Guang-Hui Liu

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.